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Menampilkan 11–20 dari 2312 artikel
Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Design and Evaluation of Hazard Analysis Procedures in Mining Occupational Safety Programs
Workplace accidents in the mining industry remain high, highlighting the need for systematic hazard analysis to strengthen Occupational Health and Safety (OHS) programs. This study aims to design and evaluate a Hazard Analysis Procedure (HAP) model for PT. XYZ. Using quantitative methods, the research applied the Fuzzy Delphi technique to validate OHS parameters and the Fuzzy Analytic Hierarchy Process (FAHP) to determine their relative weights. Data were obtained from ten certified OHS experts...
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Exploring Serum Bilirubin as a Potential Biomarker for Primary Open-Angle Glaucoma
Total bilirubin (TBIL) functions as a natural antioxidant, and its levels tend to decrease with increasing oxidative stress, including in glaucoma tissue. This study aims to explore the relationship between total serum bilirubin levels and the severity of primary open-angle glaucoma (POAG). A total of 25 POAG patients and 25 control subjects further divided into aged >60 years and ≤60 years from the Glaucoma Clinic of the Universitas Sumatera Utara Hospital and its affiliated hospitals were i...
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Analysis of the Efficiency of Universal Bacterial Filters with the Adapter Port on the GE Carescape R860 Ventilator Using the Uncertainty Method
Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
; Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The frequency of filter replacement that must always be replaced increases the hospital's budget requirements for consumables (BHP). An alternative solution is to replace the original filter with a universal filter with the addition of ports so that it can be compatible on the ventilator machine. This study aims to analyze the effect of using universal bacterial filters modified with ports to be compatible with ventilators. The research was conducted with a quantitative approach and internal and...
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The challenges of recovery resilience in drug addicted clients: An addiction counselor's perspective
Drug addiction is a problem for addicted clients who need help recovering from addiction counselors. However, the challenges of resilience to recovery in the outpatient rehabilitation process are caused by social stress and the lack of meaning in life. Therefore, the research objective was to explore the challenges of resilience in recovery from drug addiction from the perspective of addiction counselors. A descriptive phenomenological design was used, supported by in-depth interviews with two p...
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Effect of Printing Speed on the Properties of 3D Printed Products Using Recycled PET Filament
Fitriyana, Deni Fajar
; Agung Efriyo Hadi
; Nugroho Suhodo
; Aldias Bahatmaka
; Januar Parlaungan Siregar
; Tezara Cionita
; Zuhriyan Ash Shiddieqy Bahlawan
; Achmad Yanuar Maulana
Recycled PET has been widely studied for its potential use in 3D printing applications. However, few research has examined how printing speed affects recycled PET filament products' mechanical and physical qualities. This research examines how printing speed influences the physical and mechanical qualities of 3D-printed PET filament goods created from mineral water bottle trash. In this study, filament fabrication is carried out using the homemade pultrusion machine, then the filament is used fo...
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Exploring Mathematics Teachers’ Perceptions of ChatGPT for Personalized Learning and Technology Dependence
The development of artificial intelligence, particularly ChatGPT, has begun to influence mathematics learning in classrooms. This technology is not only used as a learning support tool but also affects how teachers teach and how students understand mathematical concepts. This study aims to analyze the effectiveness of ChatGPT in mathematics learning, its benefits and challenges, and the potential for technology dependence based on mathematics teachers’ perspectives. This study employed a System...
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Strengthening the Capacity of PMI Volunteers Through Family Care Training and Field Practice in Nursing Homes
mugiyanto, mugi
; Hadi, Syaikhul
; Yuli Astuti, Anna Kartika
; Hastuti, Diah
; ., mugiyanto
; Hadi, Syaikhul
; Yuli Astuti, Anna Kartika
; Hastuti, Diah
Jurnal Pengabdian Multidisiplin dan Pemberdayaan Masyarakat: Abdikes Trada
Vol 3
, No 1
(2026)
The capacity building program for Indonesian Red Cross Volunteers through integrated family care training with field practice is crucial. The background of this activity is based on the increasing need for elderly health services that require the support of skilled caregivers, while the capacity of volunteers to provide basic assistance in family care is still limited. Therefore, the role of Indonesian Red Cross Volunteers as Cargivers is very important in the quality of life of the elderly, esp...
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Effect of Freeze-Dried and Oven-Dried Cilembu Sweet Potato Flour on the Antioxidant Activity of Chicken Meatballs.
Putra, Azchar Prianka Piawan
; Sirajuddin, Muhammad Mar'ie
; Malik, Hotlan
; Husein, Muhammad
; Riskayanti, Riskayanti
; Prasetya, Rizki
; Haryati, Stefani Fitri
; Arief, Fitri Armianti
; Dami, Juni Claudia
; Amalia, Ditasari
; Masruri, Alvin
This study evaluated the effect of different dehydration methods, specifically oven drying (60°C) and freeze-drying (-20°C to 65°C), on the antioxidant activity of Cilembu sweet potato (Ipomoea batatas L. Lam) flour and its functional application in chicken meatballs. The antioxidant capacity was measured using the DPPH radical scavenging assay, with results showing that freeze-drying significantly preserved higher levels of bioactive compounds compared to thermal evaporation. Freeze-dried tuber...
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Gerakan Pilah Sampah dari Rumah: Edukasi Kompos dan Pengelolaan Sampah Organik menuju Gaya Hidup Berkelanjutan
Hidayah, Fitria Fatichatul
; Yuliyanto, Eko
; Saharani, Aqlia
; Damayanti, Diah
; Mirza, Saif Revalindo
; Akmal, Achmad Ridlwan
Jurnal Inovasi dan Pengabdian Masyarakat Indonesia
Vol 5
, No 2
(2026)
Latar belakang: Timbunan sampah rumah tangga di lingkungan permukiman semakin meningkat. Keberadaan sampah yang menumpuk tanpa pengelolaan yang baik dapat menimbulkan dampak buruk berkaitan dengan kesehatan dan kebersihan lingkungan. Di sisi lain, masyarakat belum memiliki kesadaran dan keterampilan yang cukup dalam mengelola sampah rumah tangga. Tujuan: Untuk mengetahui opini terkait gaya hidup berkelanjutan dan meningkatkan pengetahuan tentang pengolahan sampah organik menjadi pupuk kompos seb...
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