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Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Optimization of Tracking Algorithm on Mouse Movement Monitoring Platform in Medical Testing
Ibrahim, Sutrisno
; Rohmani, Rahmat
; Hariyono, Joko
; Rahutomo, Faisal
; Wiyono, Nanang
; Yudhani, Ratih
Accurate monitoring of mouse behavior in the Elevated Plus Maze (EPM) is essential for anxiety-related biomedical research, yet manual observation is time-consuming, subjective, and prone to human error. This study proposes an optimized automated tracking framework that integrates YOLOv8 detection with tracking methods including an adaptive Kalman Filter and DeepSORT, and compares them with conventional trackers such as CSRT and GOTURN. System performance was evaluated using Intersection over Un...
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CFD Simulation of Flame Characteristics Resulting from Volatile Matter Combustion of Various Biomass Pellets
Fitrah, Ramavi Akbar Akhsanul
; Kusumaningtyas, Ratna Dewi
; Widjanarko, Dwi
; Widyastuti, Catur Rini
; Hidayat, Muslikhin
; Aziz, Muhammad
While biomass is a promising carbon-neutral alternative to coal, the specific volatile matter (VM) flame characteristics of diverse biomass pellets, particularly water hyacinth, remain under-researched. This study uses a numerical CFD approach (Ansys Fluent) to investigate how varying VM fractions influence flame structure in a 2D planar slice of the furnace block (25 cm width). Simulations employed the SST k–ω turbulence and Eddy dissipation model to capture mixing-limited chemical reactions. B...
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Inovasi Desalinasi Terpadu untuk Kemandirian Air Bersih dan Ketahanan Pangan di Desa Pesisir: KolaborasiPetani, BUMDes, dan Tempat Ibadah: Integrated Desalination Innovation for Clean Water Independence and Food Security in Coastal Villages: Collaboration Farmers, Village-Owned Enterprises, and Places of Worship
Irawansah, Opi
; Susanti, Susanti
; Ma’ruf, Anwar
; Nurwibowo, Fajar
; Hikmawati, Isna
; Sapundani, Rum
; Almahdi, Nuh
; Miftah, Rasyid
; Rizkya, Dayna
; Zaqia Alwi, Myra
; Putri Maulida, Nandita Vitarin
; Nurwibowo, Fajar
Ujung Alang Village, located in Kampung Laut Subdistrict, Cilacap Regency, is a coastal area facing critical challenges in freshwater availability due to seawater intrusion and limited access to clean water sources. This condition affects domestic needs, sanitation, and the productivity of local agriculture. The Kosabangsa 2025 Program was implemented as a strategic effort to enhance water self-sufficiency and food security through the application of solar-powered Reverse Osmosis (RO) desalinati...
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Hospital Building Value Engineering Strategy in Accordance with Building Technical Standards
This study developed a Value Engineering strategy for hospital buildings in accordance with Indonesian technical standards, namely Government Regulation No. 16, Minister of Health Regulation No. 40, and Minister of Public Works and Public Housing Regulation No. 21 concerning Green Building Performance Assessment. The purpose of this study was to determine design-appropriate variable criteria and formulate improvement strategies for variables that did not meet the requirements. A quantitative met...
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Evaluating Behavior-Driven Metrics in Gamified Hybrid Environments: A Structural Analysis Approach
Henka Bayu Seta
; Zatin Niqotaini
; Sarika Afrizal
; Theresiawati
; Artika Arista
; Rapolo Joshua Napitupulu
; Muhammad Ibrahim Al Farisi
Despite the widespread adoption of gamification in higher education, a significant research gap remains regarding the structural pathways through which specific game elements influence psychological drivers and academic success in hybrid settings. This study addresses this by evaluating the impact of badges, points, progress bars, and leaderboards on student motivation and outcomes using a quantitative approach with a sample of 437 university students in Indonesia. Data were analyzed using Parti...
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A data analytics driven digital supervision model for enhancing school counselors’ competencies in the era of technological transformation
This study addresses the need to enhance school counselors’ professional competencies through innovative supervision approaches in the era of digital transformation. The study aimed to develop and validate a data analytics-based digital supervision model for school counseling using a mixed-methods design. The quantitative phase involved 150 school counselors whose competencies were measured using a validated scale (Cronbach’s ? = .89). Results showed a significant increase in competency scores f...
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A CIA-based Sustainable Security Risk Mitigation Model for E-Certificate Systems
Suharsono, Teguh Nurhadi
; Choi , John
; Agusiady , Raden Ricky
; Saepudin, Didin
; Sukadwilinda
; Purwanto, Heri
; Savitri , Peti
; Munastha, Ketut Abimanyu
E-certificates are increasingly adopted across sectors, yet existing studies have not developed an integrated risk mitigation model that combines CIA-based sustainable security with operational and stakeholder perspectives. Current frameworks primarily address isolated technical risks or focus on general PKI security, leaving a gap in holistic modeling tailored to end-to-end e-certificate implementation. This study addresses this gap by proposing a Sustainable Security Risk Mitigation Model for...
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The challenges of recovery resilience in drug addicted clients: An addiction counselor's perspective
Drug addiction is a problem for addicted clients who need help recovering from addiction counselors. However, the challenges of resilience to recovery in the outpatient rehabilitation process are caused by social stress and the lack of meaning in life. Therefore, the research objective was to explore the challenges of resilience in recovery from drug addiction from the perspective of addiction counselors. A descriptive phenomenological design was used, supported by in-depth interviews with two p...
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Maternal and Child Characteristics, Stimulation Practices, and Their Association with Stunting: A Cross-Sectional Study
Wijayanti, Anisa Catur
; Isnaeani, Farida Nur
; Wulandari, Windi
; Werdani, Kusuma Estu
; Puspita, Widya Galih
; Pratiwi, Septiani Cipta
; Sahda, Renaya Amelia
Jurnal Kesehatan
Vol 19
, No 1
(2026)
Pendahuluan: Stunting adalah bentuk malnutrisi kronis pada masa kanak-kanak yang mengganggu pertumbuhan fisik, perkembangan kognitif dan motorik, serta produktivitas jangka panjang. Puskesmas Trucuk II di Kabupaten Klaten memiliki prevalensi stunting tertinggi di kabupaten tersebut (22,7%). Penelitian ini mengkaji perbedaan usia anak, usia ibu, stimulasi, dan perkembangan anak dalam kaitannya dengan kejadian stunting. Metode: Penelitian potong lintang dilakukan di wilayah kerja Puskesmas Trucuk...
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