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Menampilkan 31–40 dari 7429 artikel
Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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DETERMINASI TAX COMPLIANCE: PERAN DIGITAL TAXATION, FINANCIAL LITERACY, DAN TRUST IN AUTHORITY
Jurnal Akuntansi, Keuangan dan Auditing
Vol 7
, No 1
(2026)
ABSTRAK
Perkembangan sistem perpajakan digital secara pesat telah mengubah lanskap kepatuhan pajak, khususnya di kalangan Generasi Z yang melek teknologi. Penelitian ini secara empiris mengkaji pengaruh digital taxation, literasi keuangan, dan kepercayaan pada otoritas pajak terhadap kepatuhan pajak sukarela pada Generasi Z di Indonesia tahun 2024. Populasi penelitian adalah pekerja Generasi Z. Sampel penelitian berjumlah 123 sampel, dengan menggunakan purposive sampling. Pendekatan metode kuan...
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FTFPOS-IDF: A Fuzzy Rule-Based Thematic Term Weighting Scheme for Bloom's Taxonomy Question Classification
The increasing adoption of Artificial Intelligence (AI) in education has created a growing demand for automated and reliable assessment systems. Existing Bloom’s Taxonomy (BT) question classification approaches commonly rely on TF-IDF-based weighting schemes, which assign static term weights and often fail to capture the varying thematic importance of terms across cognitive levels. To address this limitation, this study proposes a novel Fuzzy Thematic Feature and Part-of-Speech Inverse Document...
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Optimization of Tracking Algorithm on Mouse Movement Monitoring Platform in Medical Testing
Ibrahim, Sutrisno
; Rohmani, Rahmat
; Hariyono, Joko
; Rahutomo, Faisal
; Wiyono, Nanang
; Yudhani, Ratih
Accurate monitoring of mouse behavior in the Elevated Plus Maze (EPM) is essential for anxiety-related biomedical research, yet manual observation is time-consuming, subjective, and prone to human error. This study proposes an optimized automated tracking framework that integrates YOLOv8 detection with tracking methods including an adaptive Kalman Filter and DeepSORT, and compares them with conventional trackers such as CSRT and GOTURN. System performance was evaluated using Intersection over Un...
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CFD Simulation of Flame Characteristics Resulting from Volatile Matter Combustion of Various Biomass Pellets
Fitrah, Ramavi Akbar Akhsanul
; Kusumaningtyas, Ratna Dewi
; Widjanarko, Dwi
; Widyastuti, Catur Rini
; Hidayat, Muslikhin
; Aziz, Muhammad
While biomass is a promising carbon-neutral alternative to coal, the specific volatile matter (VM) flame characteristics of diverse biomass pellets, particularly water hyacinth, remain under-researched. This study uses a numerical CFD approach (Ansys Fluent) to investigate how varying VM fractions influence flame structure in a 2D planar slice of the furnace block (25 cm width). Simulations employed the SST k–ω turbulence and Eddy dissipation model to capture mixing-limited chemical reactions. B...
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Inovasi Desalinasi Terpadu untuk Kemandirian Air Bersih dan Ketahanan Pangan di Desa Pesisir: KolaborasiPetani, BUMDes, dan Tempat Ibadah: Integrated Desalination Innovation for Clean Water Independence and Food Security in Coastal Villages: Collaboration Farmers, Village-Owned Enterprises, and Places of Worship
Irawansah, Opi
; Susanti, Susanti
; Ma’ruf, Anwar
; Nurwibowo, Fajar
; Hikmawati, Isna
; Sapundani, Rum
; Almahdi, Nuh
; Miftah, Rasyid
; Rizkya, Dayna
; Zaqia Alwi, Myra
; Putri Maulida, Nandita Vitarin
; Nurwibowo, Fajar
Ujung Alang Village, located in Kampung Laut Subdistrict, Cilacap Regency, is a coastal area facing critical challenges in freshwater availability due to seawater intrusion and limited access to clean water sources. This condition affects domestic needs, sanitation, and the productivity of local agriculture. The Kosabangsa 2025 Program was implemented as a strategic effort to enhance water self-sufficiency and food security through the application of solar-powered Reverse Osmosis (RO) desalinati...
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Analysis of the Implementation of Hospital Management Information Systems Using the HOT-Fit Method at Sebelas Maret University Hospital
LUTHFIYYAH, ANGGRAINI
; Regina Putri, Frestiany
; Ratri Sukmaningsih, Wahyu
; Syarry Handoko, Anggraini Luthfiyyah
; Regina Putri, Frestiany
; Ratri Sukmaningsih, Wahyu
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The implementation of the Hospital Management Information System (SIMRS) is an important part of supporting fast, accurate, and integrated health services. Sebelas Maret University Hospital has implemented the Techno Medic application to support Electronic Medical Records (EMR) in outpatient services. This study aims to determine the implementation of SIMRS based on the HOT-Fit approach, which includes Human, Organization, Technology, and Benefit aspects. The study used a qualitative descriptive...
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A CIA-based Sustainable Security Risk Mitigation Model for E-Certificate Systems
Suharsono, Teguh Nurhadi
; Choi , John
; Agusiady , Raden Ricky
; Saepudin, Didin
; Sukadwilinda
; Purwanto, Heri
; Savitri , Peti
; Munastha, Ketut Abimanyu
E-certificates are increasingly adopted across sectors, yet existing studies have not developed an integrated risk mitigation model that combines CIA-based sustainable security with operational and stakeholder perspectives. Current frameworks primarily address isolated technical risks or focus on general PKI security, leaving a gap in holistic modeling tailored to end-to-end e-certificate implementation. This study addresses this gap by proposing a Sustainable Security Risk Mitigation Model for...
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From wisdom to life satisfaction: Unpacking the mediating role of gratitude
Adolescents’ life satisfaction is an important indicator of subjective well-being and has been associated with better mental health and academic adjustment. This study examined the effect of wisdom on life satisfaction among high school students and tested gratitude as a mediator of this relationship. A quantitative cross-sectional design was employed using simple mediation analysis (PROCESS Macro Model 4). The participants were 544 high school students in Semarang, selected through random sampl...
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The challenges of recovery resilience in drug addicted clients: An addiction counselor's perspective
Drug addiction is a problem for addicted clients who need help recovering from addiction counselors. However, the challenges of resilience to recovery in the outpatient rehabilitation process are caused by social stress and the lack of meaning in life. Therefore, the research objective was to explore the challenges of resilience in recovery from drug addiction from the perspective of addiction counselors. A descriptive phenomenological design was used, supported by in-depth interviews with two p...
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