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Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Analisis Implementasi Keselamatan,Kesehatan Kerja, dan Lingkungan (K3L) dalam Pelaksanaan Praktik Di Workshop Politeknik Gajah Tunggal
Journal of Occupational Health, Hygiene and Safety
Vol 3
, No 1
(2026)
Research conducted at the Gajah Tunggal Polytechnic aims to explore the implementation of safety, health, security and environmental (K3L) practices in mechanical engineering workshops. The results show that students have a good understanding of work safety, with 96.8% of them aware of the potential dangers that exist in the workshop environment. Even though the majority of students, namely 82.25%, use personal protective equipment (PPE) during practicum, there are still 17.75% who do not use it...
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Application of LSTM and MODIS Satellite Imagery for Forecasting Oceanographic Dynamics and Identifying Potential Fishing Zones in the Sunda Strait
Khalifa, Muta Ali
; Yudono, Muchtar Ali Setyo
; Prabowo, Nico Wantona
; Santoso, Prakas
; Rachmanto, Farhan
; Prasetia, Aditya Teguh
This study integrates AQUA-MODIS satellite imagery with the Long Short-Term Memory (LSTM) model to forecast oceanographic dynamics and identify Potential Fishing Zones (PFZ) in the Sunda Strait. The dataset spanning from January 2014 to December 2024 was used for model training, while forecasts for January–August 2025 were validated using in-situ observations from six sampling stations. The model predicted sea surface temperature (SST), chlorophyll-a concentration, and ocean current speed, with...
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FTFPOS-IDF: A Fuzzy Rule-Based Thematic Term Weighting Scheme for Bloom's Taxonomy Question Classification
The increasing adoption of Artificial Intelligence (AI) in education has created a growing demand for automated and reliable assessment systems. Existing Bloom’s Taxonomy (BT) question classification approaches commonly rely on TF-IDF-based weighting schemes, which assign static term weights and often fail to capture the varying thematic importance of terms across cognitive levels. To address this limitation, this study proposes a novel Fuzzy Thematic Feature and Part-of-Speech Inverse Document...
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ECCFD-GNN: A Novel Risk-Sensitive Graph Neural Network Model for Fraudulent Transaction Detection
The study presents the integration of machine learning techniques for detecting the credit card fraud. Its integration maintains a behavioral profile of cardholders and other parameters like location, frequency, amount etc. resulting in the timely detection of any anomaly from the normal behavior. A novel approach ECCFD-GNN (Enhanced Credit Card Fraud Detection based on Graph Neural networks) is proposed enhancing the performance of fraud detection. The various behavioral indicators taken into c...
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Inovasi Desalinasi Terpadu untuk Kemandirian Air Bersih dan Ketahanan Pangan di Desa Pesisir: KolaborasiPetani, BUMDes, dan Tempat Ibadah: Integrated Desalination Innovation for Clean Water Independence and Food Security in Coastal Villages: Collaboration Farmers, Village-Owned Enterprises, and Places of Worship
Irawansah, Opi
; Susanti, Susanti
; Ma’ruf, Anwar
; Nurwibowo, Fajar
; Hikmawati, Isna
; Sapundani, Rum
; Almahdi, Nuh
; Miftah, Rasyid
; Rizkya, Dayna
; Zaqia Alwi, Myra
; Putri Maulida, Nandita Vitarin
; Nurwibowo, Fajar
Ujung Alang Village, located in Kampung Laut Subdistrict, Cilacap Regency, is a coastal area facing critical challenges in freshwater availability due to seawater intrusion and limited access to clean water sources. This condition affects domestic needs, sanitation, and the productivity of local agriculture. The Kosabangsa 2025 Program was implemented as a strategic effort to enhance water self-sufficiency and food security through the application of solar-powered Reverse Osmosis (RO) desalinati...
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Analysis of the Implementation of Hospital Management Information Systems Using the HOT-Fit Method at Sebelas Maret University Hospital
LUTHFIYYAH, ANGGRAINI
; Regina Putri, Frestiany
; Ratri Sukmaningsih, Wahyu
; Syarry Handoko, Anggraini Luthfiyyah
; Regina Putri, Frestiany
; Ratri Sukmaningsih, Wahyu
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The implementation of the Hospital Management Information System (SIMRS) is an important part of supporting fast, accurate, and integrated health services. Sebelas Maret University Hospital has implemented the Techno Medic application to support Electronic Medical Records (EMR) in outpatient services. This study aims to determine the implementation of SIMRS based on the HOT-Fit approach, which includes Human, Organization, Technology, and Benefit aspects. The study used a qualitative descriptive...
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Evaluating Behavior-Driven Metrics in Gamified Hybrid Environments: A Structural Analysis Approach
Henka Bayu Seta
; Zatin Niqotaini
; Sarika Afrizal
; Theresiawati
; Artika Arista
; Rapolo Joshua Napitupulu
; Muhammad Ibrahim Al Farisi
Despite the widespread adoption of gamification in higher education, a significant research gap remains regarding the structural pathways through which specific game elements influence psychological drivers and academic success in hybrid settings. This study addresses this by evaluating the impact of badges, points, progress bars, and leaderboards on student motivation and outcomes using a quantitative approach with a sample of 437 university students in Indonesia. Data were analyzed using Parti...
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Analysis of the Efficiency of Universal Bacterial Filters with the Adapter Port on the GE Carescape R860 Ventilator Using the Uncertainty Method
Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
; Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The frequency of filter replacement that must always be replaced increases the hospital's budget requirements for consumables (BHP). An alternative solution is to replace the original filter with a universal filter with the addition of ports so that it can be compatible on the ventilator machine. This study aims to analyze the effect of using universal bacterial filters modified with ports to be compatible with ventilators. The research was conducted with a quantitative approach and internal and...
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Analysis of Factors Affecting the Length of Postoperative Patient Care at RSUD Bung Karno Surakarta
-, Dyah Ayu Pitaloka
; Wulandari, Sri
; Widyoko, Aries
; Ayu Pitaloka, Dyah
; Wulandari, Sri
; Widyoko, Aries
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
A health service facility is a tool and/or place used to carry out health service efforts, both promotive, preventive, curative and rehabilitative. Hospitals must pay attention to the quality and safety of patients. One of the indicators of the quality of hospital inpatient services is Length of Stay (LOS). This study aims to analyze the factors that affect the Length of Stay (LOS) of postoperative patients at Bung Karno Hospital Surakarta and determine the most dominant factors. The research me...
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