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Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Hubungan Karakteristik Individu, Kepribadian Hardiness, dan Dukungan Sosial terhadap Stres Kerja pada Pengendara Ojek Online
Journal of Occupational Health, Hygiene and Safety
Vol 3
, No 1
(2026)
Seiring dengan perkembangan ilmu pengetahuan, budaya, dan teknologi bersamaan dengan meningkatnya kebutuhan masyarakat, maka terjadi perubahan pada aktivitas sehari-hari dan pekerjaan di masyarakat yang menciptakan pekerjaan baru, salah satunya adalah ojek online yang merupakan perkembangan transportasi berbasis aplikasi. maraknya penggunaan transportasi online berpotensi menimbulkan permasalahan keselamatan dan kesehatan kerja bagi pengemudi ojek online yakni stres kerja. Tujuan penelitian ini...
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DETERMINASI TAX COMPLIANCE: PERAN DIGITAL TAXATION, FINANCIAL LITERACY, DAN TRUST IN AUTHORITY
Jurnal Akuntansi, Keuangan dan Auditing
Vol 7
, No 1
(2026)
ABSTRAK
Perkembangan sistem perpajakan digital secara pesat telah mengubah lanskap kepatuhan pajak, khususnya di kalangan Generasi Z yang melek teknologi. Penelitian ini secara empiris mengkaji pengaruh digital taxation, literasi keuangan, dan kepercayaan pada otoritas pajak terhadap kepatuhan pajak sukarela pada Generasi Z di Indonesia tahun 2024. Populasi penelitian adalah pekerja Generasi Z. Sampel penelitian berjumlah 123 sampel, dengan menggunakan purposive sampling. Pendekatan metode kuan...
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Application of LSTM and MODIS Satellite Imagery for Forecasting Oceanographic Dynamics and Identifying Potential Fishing Zones in the Sunda Strait
Khalifa, Muta Ali
; Yudono, Muchtar Ali Setyo
; Prabowo, Nico Wantona
; Santoso, Prakas
; Rachmanto, Farhan
; Prasetia, Aditya Teguh
This study integrates AQUA-MODIS satellite imagery with the Long Short-Term Memory (LSTM) model to forecast oceanographic dynamics and identify Potential Fishing Zones (PFZ) in the Sunda Strait. The dataset spanning from January 2014 to December 2024 was used for model training, while forecasts for January–August 2025 were validated using in-situ observations from six sampling stations. The model predicted sea surface temperature (SST), chlorophyll-a concentration, and ocean current speed, with...
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FTFPOS-IDF: A Fuzzy Rule-Based Thematic Term Weighting Scheme for Bloom's Taxonomy Question Classification
The increasing adoption of Artificial Intelligence (AI) in education has created a growing demand for automated and reliable assessment systems. Existing Bloom’s Taxonomy (BT) question classification approaches commonly rely on TF-IDF-based weighting schemes, which assign static term weights and often fail to capture the varying thematic importance of terms across cognitive levels. To address this limitation, this study proposes a novel Fuzzy Thematic Feature and Part-of-Speech Inverse Document...
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Evaluating Behavior-Driven Metrics in Gamified Hybrid Environments: A Structural Analysis Approach
Henka Bayu Seta
; Zatin Niqotaini
; Sarika Afrizal
; Theresiawati
; Artika Arista
; Rapolo Joshua Napitupulu
; Muhammad Ibrahim Al Farisi
Despite the widespread adoption of gamification in higher education, a significant research gap remains regarding the structural pathways through which specific game elements influence psychological drivers and academic success in hybrid settings. This study addresses this by evaluating the impact of badges, points, progress bars, and leaderboards on student motivation and outcomes using a quantitative approach with a sample of 437 university students in Indonesia. Data were analyzed using Parti...
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Analysis of the Efficiency of Universal Bacterial Filters with the Adapter Port on the GE Carescape R860 Ventilator Using the Uncertainty Method
Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
; Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The frequency of filter replacement that must always be replaced increases the hospital's budget requirements for consumables (BHP). An alternative solution is to replace the original filter with a universal filter with the addition of ports so that it can be compatible on the ventilator machine. This study aims to analyze the effect of using universal bacterial filters modified with ports to be compatible with ventilators. The research was conducted with a quantitative approach and internal and...
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Analysis of Cardiac Arrhythmia Detection Using Spectrograms and Convolutional Neural Networks (CNN) for Nursing Care
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
Cardiac arrhythmia is a leading cause of sudden death, requiring rapid detection in emergency department nursing care. Manual interpretation of electrocardiograms (ECGs) is often time-consuming and prone to human error. This study aims to develop a lightweight and accurate automated arrhythmia classification system using a deep learning approach. The proposed method transforms one-dimensional ECG signals into two-dimensional visual representations in the form of spectrograms using the Short-Time...
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Maternal and Child Characteristics, Stimulation Practices, and Their Association with Stunting: A Cross-Sectional Study
Wijayanti, Anisa Catur
; Isnaeani, Farida Nur
; Wulandari, Windi
; Werdani, Kusuma Estu
; Puspita, Widya Galih
; Pratiwi, Septiani Cipta
; Sahda, Renaya Amelia
Jurnal Kesehatan
Vol 19
, No 1
(2026)
Pendahuluan: Stunting adalah bentuk malnutrisi kronis pada masa kanak-kanak yang mengganggu pertumbuhan fisik, perkembangan kognitif dan motorik, serta produktivitas jangka panjang. Puskesmas Trucuk II di Kabupaten Klaten memiliki prevalensi stunting tertinggi di kabupaten tersebut (22,7%). Penelitian ini mengkaji perbedaan usia anak, usia ibu, stimulasi, dan perkembangan anak dalam kaitannya dengan kejadian stunting. Metode: Penelitian potong lintang dilakukan di wilayah kerja Puskesmas Trucuk...
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Differences in Knowledge Levels in Providing Online Fire Simulations and Offline Fire Simulations at a Steel Manufacturing Company in Semarang
Jurnal Kesehatan
Vol 19
, No 1
(2026)
Pendahuluan: Perusahaan manufaktur besi dan baja memiliki potensi bahaya kebakaran yang tinggi karena proses produksinya menggunakan suhu di atas 400°C. Oleh karena itu, kemampuan pekerja dalam menurunkan risiko kebakaran dan merespons keadaan darurat kebakaran sangat diperlukan. Metode: Penelitian ini merupakan penelitian kuantitatif dengan metode kuasi-eksperimen menggunakan desain pre-test dan post-test. Penelitian melibatkan 50 pekerja yang dibagi menjadi dua kelompok. Kelompok pertama mend...
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