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Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Digital Lean-Process Framework for Creative-Industry Efficiency (Case: Sipirok, Indonesia)
This study develops a community empowerment model for the creative economy by integrating local wisdom, education, institutional support, and technology while applying Value Stream Mapping (VSM) to reduce process inefficiencies affecting sustainable tourism. The research introduces Lean-based process optimization using engineering metrics such as cycle time, uptime, and defect ratio. Results indicate that Lean interventions reduced cycle time by 25.3%, increased uptime by 6.8%, and decreased wai...
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PENGARUH TRANSAKSI PIHAK BERELASI TERHADAP KECURANGAN LAPORAN KEUANGAN DENGAN KEPEMILIKAN MANAJERIAL SEBAGAI VARIABEL MODERASI
Jurnal Akuntansi, Keuangan dan Auditing
Vol 6
, No 2
(2026)
Penelitian ini bertujuan untuk mengetahui pengaruh transaksi pihak berelasi dan koneksi politik terhadap kecurangan laporan keuangan dengan kepemilikan manajerial sebagai variabel pemoderasi. Populasi penelitian ini sebanyak 178 perusahaan manufaktur yang diperoleh dari situs idx dan beberapa dari situs resmi masing-masing perusahaan dengan metode pengambilan sampel purposive sampling, diperoleh sampel sebanyak 33 perusahaan untuk 5 tahun pengamatan dengan melihat laporan keuangan dan tahunan se...
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Optimizing Cost Performance in Green Industrial Palm Oil Projects Using AI-Based AEC
Advance Sustainable Science, Engineering and Technology (ASSET)
Vol 8
, No 1
(2026)
This study investigates green industrial palm oil project cost performance determinants through Artificial Intelligence (AI)-based Architecture, Engineering, and Construction (AEC) systems. The study employed a Structural Equation Modeling Partial Least Squares (SEM-PLS) approach to analyze significant data collected from 115 respondents through 166 validated indicators. Ten primary drivers were identified, and alternative water sources topped the list, followed by indoor air quality auditing, g...
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Prediksi Penyakit Jantung Menggunakan Algoritma Machine Learning Berdasarkan Indikator Kesehatan
Karo-Karo, Julkarnaen
; Syakir, Adryan Raihan
; Raihan, Raihan
; Sumanto, Sumanto
; Budiawan, Imam
; Pakpahan, Roida
; Christian, Ade
; Karo-Karo, Julkarnaen
; Syakir, Adryan Raihan
; Raihan, Raihan
; Sumanto, Sumanto
; Budiawan, Imam
; Pakpahan, Roida
; Christian, Ade
JUISI : Jurnal Ilmiah Sistem Informasi
Vol 5
, No 1
(2025)
Penyakit jantung tetap menjadi penyebab utama kematian di seluruh dunia, sehingga menekankan perlunya deteksi dini dan langkah pencegahan aktif melalui pendekatan yang didasarkan pada analisis data. Penelitian ini bertujuan untuk memprediksi kemungkinan terjadinya penyakit jantung dengan memanfaatkan berbagai metode pembelajaran mesin, yang bergantung pada indikator kesehatan seperti nilai tekanan darah, tingkat kolesterol, indeks massa tubuh, serta pengukuran denyut nadi. Penelitian ini menerap...
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Hubungan Dukungan Keluarga dan Kualitas Hidup pada Pasien Diabetes Melitus di Rumah Sakit Santa Elisabeth Medan
Jurnal Ventilator: Jurnal riset ilmu kesehatan dan Keperawatan
Vol 3
, No 4
(2025)
Diabetes mellitus is the second leading cause of death worldwide after cardiovascular disease. This condition causes physical and psychological burdens. Quality of life is influenced by various aspects, including the ongoing special needs of diabetes mellitus patients. Family support is a form of assistance provided by family members to provide physical and psychological comfort when someone is ill. This study aims to determine the relationship between family support and quality of life of diabe...
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Dari Buku ke Layar: Inovasi Media Digital dalam Merancang Bahan Ajar Sejarah yang Interaktif bagi Siswa Gen Z SMA Negeri 1 Tebing Tinggi
Inspirasi Dunia: Jurnal Riset Pendidikan dan Bahasa
Vol 4
, No 4
(2025)
The 21st century of digitalization is very influential in life such as Education which must adapt to the development of world digitalization technology. Education is carried out by involving innovation, creativity, and also motivation to update more interesting learning methods with interactive media that have been designed. History learning in particular must develop and adapt to the digital era by utilizing technology to make teaching methods the goal of an active learning process. History lea...
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STUDI KOMPARATIF KELAYAKAN USAHATANI PAKCOY (BRASSICA RAPA SUBSP. CHINENSIS) SECARA HIDROPONIK DAN KONVENSIONAL
Mediagro: journal of agricultural sciences
Vol 21
, No 3
(2025)
Pak choy farming is the organized cultivation of bok choy plants to produce economically valuable agricultural products. This study aims to determine the current state of hydroponic and conventional bok choy cultivation techniques and to compare the feasibility of hydroponic and conventional bok choy farming. A total of 18 bok choy farmers were interviewed. The analysis used in this study was the R/C Ratio and B/C Ratio. The results indicate that both cultivation methods are feasible because the...
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PENGARUH PARIWISATA TERHADAP PELESTARIAN BAHASA DAN BUDAYA LOKAL DI TUKTUK SAMOSIR
Sinaga, Priskila Yosefina Natalia
; Yumna Afra
; Maria Thessalonika Sitorus
; Amelia Mahmuddin
; Sarah Novelina Pakpahan
; Lestari Marbun
NALAR: Jurnal Pendidikan dan Kebudayaan
Vol 4
, No 2
(2025)
Penelitian ini bertujuan untuk menganalisis pengaruh perkembangan pariwisata terhadap pelestarian bahasa dan budaya Batak di TukTuk, Samosir. Dalam konteks pariwisata yang berkembang pesat, penting untuk memahami dampak positif maupun negatif yang ditimbulkan terhadap kelestarian budaya lokal. Penelitian ini juga mengidentifikasi tantangan yang dihadapi dalam melestarikan bahasa dan budaya Batak di tengah pengaruh globalisasi dan dominasi bahasa asing. Di samping itu, penelitian ini mengkaji per...
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Digitalisasi Layanan Publik dan Dampaknya pada Ekologi Administrasi Sosial: Peluang dan Risiko
Sri Yulianty Mozin
; Romy Tantu
; Edis Adelia Dunggio
; Siti Rukiah Yusup
; Arit Pratama Putra Lihawa
; Zavicka Aulia Natasya
; Sabrina Meamogu
; Siti Fadilah Atjil
; Siti Nurain Tuna
; Nopal R. Abas
; Adeliptia Abdullah
; Raihan Alamsyah Hilapah
; Wal Fajri
Jurnal Media Administrasi
Vol 10
, No 2
(2025)
This article explores the background, methods, results, and conclusions of digitalization in public services, focusing on its impact on the social administration ecology. It examines the rapid adoption of e- government and ICT (information and communication technology) by public administrations worldwide since 2020, investigating both opportunities and risks. Methods include a systematic literature review and qualitative case studies drawn primarily from peer-reviewed journals published between...
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