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Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Workshop Pembuatan Urea Molasses Block (UMB) untuk Meningkatkan Produktivitas Ternak di Kecamatan Windusari, Kabupaten Magelang
Pradita, Linda Eka
; Manggala Wijaya, Ahmad Rino
; Oktaviana, Tiara
; Hasna Aribah, Nisrina Zaidatun
; Intan Meilisa, Maulidya
; Salman Fata, Muhammad
; Aulia, Fara
; Yuliana, Tri Wahyu
; Arifina Qulba, Shefie
; Rahayu Pramesti, Yuliani
; Luthfie Freessylia, Brilliant
; Khaidar Ali, Wildan
; Oktaviana, Tiara
Pakan adalah faktor penting dalam sektor peternakan. Bidang peternakan menjadi fokus pengembangan di Kelurahan Bandarsedayu yang terletak di Kabupaten Magelang. Kondisi geografi sesuai dengan adaptasi hewan dan sumber pakan berupa rumput yang cukup berlimpah. Namun, tidak semua rumput dapat memenuhi kebutuhan mineral ternak karena beberapa faktor. Teknologi pakan tambahan seperti Urea Molase Blok yang memiliki kandungan mineral tinggi. Tujuan dari pengabdian ini adalah untuk mengedukasi masyarak...
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Faktor-Faktor yang Mempengaruhi Implementasi SAK EMKM pada UMKM di Kota Semarang
KOMPAK : Jurnal Ilmiah Komputerisasi Akuntansi
Vol 19
, No 1
(2026)
This study aims to analyse the factors influencing the implementation of Financial Accounting Standards for Micro, Small, and Medium Enterprises (MSMEs) in Semarang City. Specifically, it examines the effects of accounting understanding, information technology utilisation, and MSME owners’ perceptions on SAK EMKM implementation, with SAK EMKM socialisation as a moderating variable. The research employs a quantitative approach using primary data collected through questionnaires distributed to 109...
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Pengaruh Pengetahuan Food Safety terhadap Perilaku Higiene Mahasiswa Pendidikan Tata Boga
Vol 5
, No 2
(2025)
Food safety is an important determinant of public health, especially in the culinary vocational education environment which is full of risks of biological, chemical, and physical contamination. The practice kitchen in the Culinary Education Study Program functions as a micro-environment that has the potential to become a source of the spread of foodborne diseases if hygiene practices are not applied consistently. However, the empirical relationship between food safety knowledge and student hygie...
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SISTEM KERJA PADA MESIN WINDING MURATEC QPRO EX DALAM PEMBUATAN BENANG
Teknika
Vol 10
, No 2
(2025)
This study aims to analyze the working system of the Winding Muratec QPRO EX machine used at PT Budi Texindo Prakarsa. The primary focus of this research is to understand the operational mechanism of the Winding Muratec QPRO EX machine, including the processes of yarn sorting and arrangement, the working principles of the system, and the identification of its main components. In addition, this study also discusses the aspects of maintenance and specific control measures required to ensure optima...
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HUBUNGAN STRESS KERJA DAN TEKANAN DARAH PADA PEKERJA INDUSTRI DI KABUPATEN SEMARANG
Nursing Science Journal
Vol 6
, No 1
(2025)
Background: The growth of the industrial sector in Indonesia has also increased the challenges of occupational health, particularly related to work stress, which can potentially impact blood pressure. Objective: This study aims to examine the relationship between work stress levels and blood pressure among industrial workers. Methods: This research uses a descriptive correlational design with a cross-sectional approach, conducted in Semarang Regency, from December 2024 to January...
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Perlindungan Hukum Pidana Atas Hak Pekerja Di PT. Medisafe Technologies (Studi di Dinas Ketenagakerjaan Kabupaten Deli Serdang)
Pangaribuan, Guntur
; Lubis, Muhammad Salim Fauzi
; Suniaprily, Firstnandiar Glica Aini
; Maria, Juliya
Jurnal Penelitian Serambi Hukum
Vol 18
, No 02
(2025)
One of the backgrounds to the birth of Law Number 13 of 2003 concerning Manpower is because several laws and regulations that have been in effect so far have placed workers in a less advantageous position in the service of manpower placement and the industrial relations system that emphasizes differences in position and interests so that they are considered no longer in accordance with current needs and future demands. The birth of Law Number 13 of 2003 concerning Manpower is expected to: Uphold...
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Pengaruh Kinerja Guru Dan Beban Kerja Terhadap Produktivitas Kerja Guru Sekolah Menengah Pertama Kecamatan Jelai Hulu
Manajemen Pendidikan
Vol 20
, No 1
(2025)
This study aims to obtain data and information on the significant influence of teacher performanceand workload on the work productivity of junior high school teachers in Jelai Hulu District. The formof this research uses a quantitative method with a descriptive approach. The population in this studyconsisted of 39 respondents, and the sampling method was saturated sampling, specifically targetingpublic junior high school teachers in the Jelai Hulu District, totaling 39 individuals. The responden...
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Expressive Speech Act In Andung-Andung Batak Toba
Jurnal Riset sosial humaniora, dan Pendidikan (Soshumdik)
Vol 3
, No 4
(2025)
This research is a type of qualitative descriptive research entitled Expressive Speech Acts in Andung-Andung Batak Toba. This study describes the form and function of expressive speech acts in andung-andung speech. The data of this study are language units in the form of words, phrases, clauses or sentences of andung-andung in 9 YouTube channels and 7 amateur videos. The data sources of this study are YouTube channels and amateur videos. Based on the research findings, it is known that there are...
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PREVENTIVE MAINTENANCE PADA GENERATOR DI PT. INDONESIA POWER UJP PLTU BANTEN 2 LABUAN
Teknika
Vol 10
, No 1
(2025)
Energi listrik memiliki peranan yang sangat penting dalam menunjang aktivitas sehari-hari, menjadikannya kebutuhan utama di berbagai sektor kehidupan, termasuk industri dan rumah tangga. Ketersediaan energi listrik yang stabil dan andal menjadi elemen vital bagi pertumbuhan ekonomi dan kesejahteraan masyarakat, terlebih di negara berkembang seperti Indonesia yang mengalami peningkatan signifikan dalam konsumsi energi. Salah satu penyedia utama energi listrik adalah Pembangkit Listrik Tenaga Uap...
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