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Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Student academic hardiness: descriptive analysis and its relationship with individual characteristic
Harahap, Ade Chita Putri
; Indreswari, Henny
; Hidayah, Nur
; Setyowati, Arbin Janu
; Ramli, M
; Makhsin, Mardzelah Binti
; Harahap, Dinda Permatasari
; Simarmata, Sari Wardani
This study aims to analyze students' academic hardiness and examine its differences based on individual characteristics as well as its relationship with academic achievement. This research employed a quantitative approach with a descriptive and correlational design. The participants consisted of 103 students selected using accidental sampling. Data were collected using a Likert-scale questionnaire measuring the dimensions of commitment, control, and challenge. Data analysis was conducted using d...
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Design and Implementation of a Web-Based QR Code Employee Attendance System for Optimizing Attendance Management: A Case Study at Bento and Es Teh Luwes Ungaran
Nufninu, Novinda Grezen
; Rudjiono, Rudjiono
; Panjaitan, Cherlina Helena Purnamasari
; Nufninu, Novinda Grezen
; Rudjiono, Rudjiono
; Panjaitan, Cherlina Helena Purnamasari
Penelitian ini dilatarbelakangi oleh proses absensi karyawan pada Stand Bento dan Stand Es Teh Luwes Ungaran yang masih dilakukan secara manual menggunakan buku absensi. Kondisi tersebut menimbulkan beberapa kendala, seperti kesalahan pencatatan jam masuk dan pulang, risiko kehilangan atau kerusakan data, serta lambatnya proses rekapitulasi laporan kehadiran. Penelitian ini bertujuan untuk merancang dan mengimplementasikan sistem absensi karyawan berbasis web menggunakan teknologi QR Code guna m...
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Effect of Freeze-Dried and Oven-Dried Cilembu Sweet Potato Flour on the Antioxidant Activity of Chicken Meatballs.
Putra, Azchar Prianka Piawan
; Sirajuddin, Muhammad Mar'ie
; Malik, Hotlan
; Husein, Muhammad
; Riskayanti, Riskayanti
; Prasetya, Rizki
; Haryati, Stefani Fitri
; Arief, Fitri Armianti
; Dami, Juni Claudia
; Amalia, Ditasari
; Masruri, Alvin
This study evaluated the effect of different dehydration methods, specifically oven drying (60°C) and freeze-drying (-20°C to 65°C), on the antioxidant activity of Cilembu sweet potato (Ipomoea batatas L. Lam) flour and its functional application in chicken meatballs. The antioxidant capacity was measured using the DPPH radical scavenging assay, with results showing that freeze-drying significantly preserved higher levels of bioactive compounds compared to thermal evaporation. Freeze-dried tuber...
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Motorcycle Passenger-Car Equivalents from Time-Headway Data with Lane-Occupancy Adjustment in Urban Indonesia
Aulia Dewi Fatikasari
; Achmad Dzulfiqar Alfiansyah
; Zaid Dzulkarnain Zubizaretta
; Rohmahillah Aviskanasya Septiandri
; Agistya Rachma Larasati
; Roma Artha Uly Napitupulu
; Linie Rose Dayaday Santacera
; Sinta Nabilah Salma
Motorcycles dominate traffic composition in East Surabaya, making the determination of Passenger Car Equivalent (PCE) values for motorcycles a crucial aspect of road performance assessment. This research evaluates motorcycle PCE value on six road sections on Raya Prapen Street, Jemursari Street, Jemur Andayani Street, Panjang Jiwo Street, Kali Rungkut Street, and Rungkut Industri Street, each observed in two directions (12 segments in total), with samples collected during peak hours on Monday (0...
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Intervensi Edukasi Reproduksi untuk Cegah Infeksi Menular Seksual pada Remaja Melalui Sekolah
Jurnal Inovasi dan Pengabdian Masyarakat Indonesia
Vol 5
, No 2
(2026)
Latar belakang: Remaja merupakan kelompok usia yang rentan terhadap infeksi menular seksual (IMS) dan human immunodeficiency virus/acquired immuno deficiency syndrome (HIV/AIDS) akibat kurangnya akses terhadap informasi kesehatan yang akurat dan edukatif. Kondisi ini menunjukkan perlunya intervensi edukatif yang sistematis dan berbasis sekolah guna meningkatkan pemahaman remaja mengenai kesehatan reproduksi serta pencegahan IMS dan HIV/AIDS. Tujuan: Kegiatan ini bertujuan untuk meningkatkan peng...
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Cost-Effectiveness of Antihypertensive Therapy in Ischemic Stroke Patients
VISIKES
Vol 25
, No 1
(2026)
Ischemic stroke is an acute condition caused by the interruption of blood flow to the brain due to blood vessel obstruction, which can lead to permanent disability and death. Hypertension is a major risk factor and the most common comorbidity in ischemic stroke patients. The use of antihypertensive therapy in stroke patients plays a crucial role in controlling blood pressure and preventing complications, but it also increases the burden of medical costs. Therefore, a pharmacoeconomic evaluation...
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Strengthening Business Networks Through Technology Utilization for MSMEs in Pegandon District
Digital technology enables the growing development of online shopping. This also makes it possible for each seller to market their products or services with a wider range and costs that are not as expensive as conventional ones. Pegandon District has many business actors or MSMEs. The GRDP growth rate in Pegandon District has not recovered after the COVID-19 pandemic. One way to increase the GRDP growth rate is to increase the capability of business actors in selling or distributing their produc...
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Digitalization Assistance Program and Human Resource Capacity Building to Enhance Transparency and Accountability of Koperasi Merah Putih in Karanganyar Gunung Village, Semarang
Widiastuti, C., T
; Sumastuti, Efriyani
; Indriasari, Ika
; Sari, Nur Latifah Dwi Mutiara
; Saputra, Risqi Dian
; Putri, Eva Yuliana
; Suroyya, Nafis
Cooperatives, as a pillar of the people’s economy, play a strategic role in improving community welfare. However, in practice, cooperatives still face various challenges, particularly in terms of digitalisation and the limited capacity of human resources (HR). This community service activity aims to enhance digital literacy and HR capacity through assistance in implementing a digital-based financial system at Koperasi Merah Putih in Karanganyar Gunung, Semarang City. The method employed is a par...
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Design of a Web-Based CRM Information System for Customer Management and Transaction History at Sumber Rejeki Store, Gubug District, Grobogan Regency
JUISI : Jurnal Ilmiah Sistem Informasi
Vol 17
, No 1
(2026)
The development of information and communication technology encourages Micro, Small, and Medium Enterprises (MSMEs) to manage data more effectively, efficiently, and integratively to create consumer loyalty. Efforts can be made using a web-based Customer Relationship Management (CRM) Information system to manage customer data and transaction history in an integrated, effective, and efficient manner. The many complaints from several stores in Grobogan Regency, especially Toko Sumber Rezeki, regar...
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