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Menampilkan 31–40 dari 6921 artikel
Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Hubungan Karakteristik Individu, Kepribadian Hardiness, dan Dukungan Sosial terhadap Stres Kerja pada Pengendara Ojek Online
Journal of Occupational Health, Hygiene and Safety
Vol 3
, No 1
(2026)
Seiring dengan perkembangan ilmu pengetahuan, budaya, dan teknologi bersamaan dengan meningkatnya kebutuhan masyarakat, maka terjadi perubahan pada aktivitas sehari-hari dan pekerjaan di masyarakat yang menciptakan pekerjaan baru, salah satunya adalah ojek online yang merupakan perkembangan transportasi berbasis aplikasi. maraknya penggunaan transportasi online berpotensi menimbulkan permasalahan keselamatan dan kesehatan kerja bagi pengemudi ojek online yakni stres kerja. Tujuan penelitian ini...
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Analisis Implementasi Keselamatan,Kesehatan Kerja, dan Lingkungan (K3L) dalam Pelaksanaan Praktik Di Workshop Politeknik Gajah Tunggal
Journal of Occupational Health, Hygiene and Safety
Vol 3
, No 1
(2026)
Research conducted at the Gajah Tunggal Polytechnic aims to explore the implementation of safety, health, security and environmental (K3L) practices in mechanical engineering workshops. The results show that students have a good understanding of work safety, with 96.8% of them aware of the potential dangers that exist in the workshop environment. Even though the majority of students, namely 82.25%, use personal protective equipment (PPE) during practicum, there are still 17.75% who do not use it...
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FTFPOS-IDF: A Fuzzy Rule-Based Thematic Term Weighting Scheme for Bloom's Taxonomy Question Classification
The increasing adoption of Artificial Intelligence (AI) in education has created a growing demand for automated and reliable assessment systems. Existing Bloom’s Taxonomy (BT) question classification approaches commonly rely on TF-IDF-based weighting schemes, which assign static term weights and often fail to capture the varying thematic importance of terms across cognitive levels. To address this limitation, this study proposes a novel Fuzzy Thematic Feature and Part-of-Speech Inverse Document...
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Optimization of Tracking Algorithm on Mouse Movement Monitoring Platform in Medical Testing
Ibrahim, Sutrisno
; Rohmani, Rahmat
; Hariyono, Joko
; Rahutomo, Faisal
; Wiyono, Nanang
; Yudhani, Ratih
Accurate monitoring of mouse behavior in the Elevated Plus Maze (EPM) is essential for anxiety-related biomedical research, yet manual observation is time-consuming, subjective, and prone to human error. This study proposes an optimized automated tracking framework that integrates YOLOv8 detection with tracking methods including an adaptive Kalman Filter and DeepSORT, and compares them with conventional trackers such as CSRT and GOTURN. System performance was evaluated using Intersection over Un...
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Metaheuristic Optimization Stacking Application for Rainfall Classification: A Comparative Study
Accurate rainfall classification plays a vital role in effective meteorological forecasting, agricultural planning, and also to avoid natural disasters. However, standard classification models often exhibit unstable performance. This study evaluates the effectiveness of an Ensemble Stacking framework enhanced with Optimized Swarm Based and Metaheuristic method such as Artificial Bee Colony (ABC) and Cuckoo Search (CS) optimization algorithms to improve prediction reliability. The proposed approa...
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ECCFD-GNN: A Novel Risk-Sensitive Graph Neural Network Model for Fraudulent Transaction Detection
The study presents the integration of machine learning techniques for detecting the credit card fraud. Its integration maintains a behavioral profile of cardholders and other parameters like location, frequency, amount etc. resulting in the timely detection of any anomaly from the normal behavior. A novel approach ECCFD-GNN (Enhanced Credit Card Fraud Detection based on Graph Neural networks) is proposed enhancing the performance of fraud detection. The various behavioral indicators taken into c...
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CFD Simulation of Flame Characteristics Resulting from Volatile Matter Combustion of Various Biomass Pellets
Fitrah, Ramavi Akbar Akhsanul
; Kusumaningtyas, Ratna Dewi
; Widjanarko, Dwi
; Widyastuti, Catur Rini
; Hidayat, Muslikhin
; Aziz, Muhammad
While biomass is a promising carbon-neutral alternative to coal, the specific volatile matter (VM) flame characteristics of diverse biomass pellets, particularly water hyacinth, remain under-researched. This study uses a numerical CFD approach (Ansys Fluent) to investigate how varying VM fractions influence flame structure in a 2D planar slice of the furnace block (25 cm width). Simulations employed the SST k–ω turbulence and Eddy dissipation model to capture mixing-limited chemical reactions. B...
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Analysis of the Implementation of Hospital Management Information Systems Using the HOT-Fit Method at Sebelas Maret University Hospital
LUTHFIYYAH, ANGGRAINI
; Regina Putri, Frestiany
; Ratri Sukmaningsih, Wahyu
; Syarry Handoko, Anggraini Luthfiyyah
; Regina Putri, Frestiany
; Ratri Sukmaningsih, Wahyu
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The implementation of the Hospital Management Information System (SIMRS) is an important part of supporting fast, accurate, and integrated health services. Sebelas Maret University Hospital has implemented the Techno Medic application to support Electronic Medical Records (EMR) in outpatient services. This study aims to determine the implementation of SIMRS based on the HOT-Fit approach, which includes Human, Organization, Technology, and Benefit aspects. The study used a qualitative descriptive...
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A data analytics driven digital supervision model for enhancing school counselors’ competencies in the era of technological transformation
This study addresses the need to enhance school counselors’ professional competencies through innovative supervision approaches in the era of digital transformation. The study aimed to develop and validate a data analytics-based digital supervision model for school counseling using a mixed-methods design. The quantitative phase involved 150 school counselors whose competencies were measured using a validated scale (Cronbach’s ? = .89). Results showed a significant increase in competency scores f...
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