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Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Analisis Penerapan K3 Laboratorium Berdsarkan Permenkes No 43 Tahun 2013 Di Laboratorium RS X. Di Kota Batam Tahun 2024
Journal of Occupational Health, Hygiene and Safety
Vol 3
, No 1
(2026)
Keselamatan dan kesehatan kerja (K3) Laboratorium ialah Segala kegiatan yang dilakukan untuk menjamin dan melindungi sumber daya manusia di fasilitas pelayanan kesehatan, termasuk pasien, pendamping pasien, karyawan, dan pengunjung rumah sakit. Penelitian ini dilakukan untuk mengetahui standar penerapan K3 di Laboratorium Rumah Sakit X Kota Batam. Jenis penelitian ini menggunakan metode deskriptif kualitatif (wawancara mendalam) dan tringulasi data . Informan dalam penelitian ini berjumlah 10 or...
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Faktor-Faktor Yang Berhubungan Dengan Kejadian Penyakit Dermatitis Kontak Pada Pengrajin Batik
Journal of Occupational Health, Hygiene and Safety
Vol 3
, No 1
(2026)
ABSTRACT
Contact dermatitis is inflammation of the skin that can be accompanied by edema between the cells in the epidermis of the skin, which is caused by exposure to chemicals in the workplace. This study aims to analyze the factors associated with contact dermatitis in batik artisan's CV. Batik Temu Jodo in PekaIongan City. Methods This research is quantitative research using a cross-sectional design approach. Primary data collection through survey method by distributing questionnaires. Until...
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Design and Evaluation of Hazard Analysis Procedures in Mining Occupational Safety Programs
Workplace accidents in the mining industry remain high, highlighting the need for systematic hazard analysis to strengthen Occupational Health and Safety (OHS) programs. This study aims to design and evaluate a Hazard Analysis Procedure (HAP) model for PT. XYZ. Using quantitative methods, the research applied the Fuzzy Delphi technique to validate OHS parameters and the Fuzzy Analytic Hierarchy Process (FAHP) to determine their relative weights. Data were obtained from ten certified OHS experts...
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Optimization of Tracking Algorithm on Mouse Movement Monitoring Platform in Medical Testing
Ibrahim, Sutrisno
; Rohmani, Rahmat
; Hariyono, Joko
; Rahutomo, Faisal
; Wiyono, Nanang
; Yudhani, Ratih
Accurate monitoring of mouse behavior in the Elevated Plus Maze (EPM) is essential for anxiety-related biomedical research, yet manual observation is time-consuming, subjective, and prone to human error. This study proposes an optimized automated tracking framework that integrates YOLOv8 detection with tracking methods including an adaptive Kalman Filter and DeepSORT, and compares them with conventional trackers such as CSRT and GOTURN. System performance was evaluated using Intersection over Un...
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Inovasi Desalinasi Terpadu untuk Kemandirian Air Bersih dan Ketahanan Pangan di Desa Pesisir: KolaborasiPetani, BUMDes, dan Tempat Ibadah: Integrated Desalination Innovation for Clean Water Independence and Food Security in Coastal Villages: Collaboration Farmers, Village-Owned Enterprises, and Places of Worship
Irawansah, Opi
; Susanti, Susanti
; Ma’ruf, Anwar
; Nurwibowo, Fajar
; Hikmawati, Isna
; Sapundani, Rum
; Almahdi, Nuh
; Miftah, Rasyid
; Rizkya, Dayna
; Zaqia Alwi, Myra
; Putri Maulida, Nandita Vitarin
; Nurwibowo, Fajar
Ujung Alang Village, located in Kampung Laut Subdistrict, Cilacap Regency, is a coastal area facing critical challenges in freshwater availability due to seawater intrusion and limited access to clean water sources. This condition affects domestic needs, sanitation, and the productivity of local agriculture. The Kosabangsa 2025 Program was implemented as a strategic effort to enhance water self-sufficiency and food security through the application of solar-powered Reverse Osmosis (RO) desalinati...
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Comparative Analysis of Manual and Electronic Medical Record Data Quality at Panti Waluyo Yakkum Hospital, Surakarta
Nurfika, Nurfika
; Wulandari, Sri
; Iskandar, Dwi
; Nurfika, Nurfika
; Wulandari, Sri
; Iskandar, Dwi
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The quality of medical record data is an important component in supporting the quality of health services, decision making, and continuity of patient services. This study aims to compare the quality of manual and electronic medical record data based on the completeness of the discharge summary at Panti Waluyo Yakkum Hospital, Surakarta. The research method used a comparative quantitative design with a cross-sectional approach on 756 samples, consisting of 378 manual medical records and 378 elect...
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Evaluating Behavior-Driven Metrics in Gamified Hybrid Environments: A Structural Analysis Approach
Henka Bayu Seta
; Zatin Niqotaini
; Sarika Afrizal
; Theresiawati
; Artika Arista
; Rapolo Joshua Napitupulu
; Muhammad Ibrahim Al Farisi
Despite the widespread adoption of gamification in higher education, a significant research gap remains regarding the structural pathways through which specific game elements influence psychological drivers and academic success in hybrid settings. This study addresses this by evaluating the impact of badges, points, progress bars, and leaderboards on student motivation and outcomes using a quantitative approach with a sample of 437 university students in Indonesia. Data were analyzed using Parti...
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Camera-Based Smart Mirror with Machine Learning for Postural Analysis: System Development and Reliability Evaluation
Early postural assessment using camera-based systems remains technically challenging due to variability in user positioning and limited evaluation of measurement repeatability. This study presents the development and repeatability evaluation of a smart mirror system for automated postural analysis using pretrained pose estimation and rule-based geometric classification. The system consists of a fixed camera mounted above a mirror and a connected computing device for real-time processing and visu...
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The challenges of recovery resilience in drug addicted clients: An addiction counselor's perspective
Drug addiction is a problem for addicted clients who need help recovering from addiction counselors. However, the challenges of resilience to recovery in the outpatient rehabilitation process are caused by social stress and the lack of meaning in life. Therefore, the research objective was to explore the challenges of resilience in recovery from drug addiction from the perspective of addiction counselors. A descriptive phenomenological design was used, supported by in-depth interviews with two p...
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