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Menampilkan 11–20 dari 1323 artikel
Low-Dose Salinomycin Targets Multidrug Resistance via P-Glycoprotein and NF-κB in Osteosarcoma Cells
Ayu, Onarisa
; Rusda, Muhammad
; Sembiring, Rosita Juwita
; Nasution, Iqbal Pahlevi Adeputra
; Mahyudin, Ferdiansyah
; Amin, Mustafa Mahmud
; Pasaribu, Hotma Partogi
; Tobing, Tina Christina Lumban
Chemotherapy resistance in osteosarcoma remains a major clinical obstacle, largely driven by drug efflux mechanisms mediated by P-glycoprotein (ACBC1/ABCB1) and activation of NF-κB signaling (NFKB1). This study investigated the potential of Salinomycin to modulate these multidrug resistance–associated genes in U2OS osteosarcoma cells and explore its role in overcoming chemoresistance. A true experimental post-test-only control group design was used. U2OS cells were treated with varying concentra...
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Analysis of the Efficiency of Universal Bacterial Filters with the Adapter Port on the GE Carescape R860 Ventilator Using the Uncertainty Method
Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
; Pramusinto, Dian Bambang
; Dwi Prasetyowati, Sri Arttini
MEDIKA TRADA : Jurnal Teknik Elektomedik Polbitrada
Vol 7
, No 1
(2026)
The frequency of filter replacement that must always be replaced increases the hospital's budget requirements for consumables (BHP). An alternative solution is to replace the original filter with a universal filter with the addition of ports so that it can be compatible on the ventilator machine. This study aims to analyze the effect of using universal bacterial filters modified with ports to be compatible with ventilators. The research was conducted with a quantitative approach and internal and...
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The challenges of recovery resilience in drug addicted clients: An addiction counselor's perspective
Drug addiction is a problem for addicted clients who need help recovering from addiction counselors. However, the challenges of resilience to recovery in the outpatient rehabilitation process are caused by social stress and the lack of meaning in life. Therefore, the research objective was to explore the challenges of resilience in recovery from drug addiction from the perspective of addiction counselors. A descriptive phenomenological design was used, supported by in-depth interviews with two p...
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Desain Karakter pada Buku Interaktif Mengenal Diri Sendiri untuk Anak Usia 9 – 11 Tahun
Citrakara
Vol 8
, No 1
(2026)
Setiap anak memiliki potensi kecerdasan yang unik dan beragam yang dapat dikategorikan dalam konsep Kecerdasan Majemuk (Multiple Intelligences). Namun, konsep Kecerdasan Majemuk ini bersifat abstrak sehingga sulit dipahami oleh anak usia 9 – 11 tahun yang berada di masa perkembangan kognitif operasional konkret Perancangan ini bertujuan untuk memvisualisasikan konsep abstrak teori Kecerdasan Majemuk (Multiple Intelligences) oleh Howard Gardner melalui pembuatan desain karakter yang secara spesif...
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Perancangan Cerita dan Desain Karakter tentang Kerentanan Lansia yang Ditinggalkan dalam Keluarga
Citrakara
Vol 8
, No 1
(2026)
Pertumbuhan jumlah lanjut usia lansia di dunia, termasuk di Indonesia, diproyeksikan terus meningkat hingga lebih dari 2 miliar pada tahun 2050. Kondisi ini menimbulkan berbagai tantangan terhadap kesejahteraan lansia, khususnya risiko penelantaran akibat rendahnya perhatian keluarga, keterbatasan ekonomi, serta minimnya dukungan sosial yang berdampak pada kesepian dan penurunan kualitas hidup. Penelitian ini bertujuan untuk merancang desain karakter dan konsep cerita yang mengangkat kerentanan...
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Social Determinants and Hypertension Incidence in Productive-Age Adults: A Literature
VISIKES
Vol 25
, No 1
(2026)
Hypertension, commonly known as high blood pressure, is a blood disorder characterized by an increase in blood pressure above the normal threshold of 140/90 mmHg during two measurements within a five-minute period in a calm state. Hypertension is one of the non-communicable diseases that causes high mortality rates in various countries. Increased blood pressure puts a heavier workload on the heart in pumping blood and circulating it throughout the body. Therefore, a person with high blood pressu...
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Cost-Effectiveness of Antihypertensive Therapy in Ischemic Stroke Patients
VISIKES
Vol 25
, No 1
(2026)
Ischemic stroke is an acute condition caused by the interruption of blood flow to the brain due to blood vessel obstruction, which can lead to permanent disability and death. Hypertension is a major risk factor and the most common comorbidity in ischemic stroke patients. The use of antihypertensive therapy in stroke patients plays a crucial role in controlling blood pressure and preventing complications, but it also increases the burden of medical costs. Therefore, a pharmacoeconomic evaluation...
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Sentiment Analysis in User Reviews of Tourist Attractions in East Nusa Tenggara Using Machine Learning Classification
Journal of Multimedia Trend and Technology
Vol 5
, No 1
(2026)
This study aims to analyze user review sentiments for six tourist attractions in East Nusa Tenggara Province by utilizing a large amount of review data obtained from Google Maps. Data was collected through a scraping process using Serp API, followed by cleaning and text pre-processing to improve data quality. Sentiment labeling was performed automatically using the Indo-BERT model to obtain three sentiment classes: positive, negative, and neutral. Text feature representation was performed using...
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Digitalization Assistance Program and Human Resource Capacity Building to Enhance Transparency and Accountability of Koperasi Merah Putih in Karanganyar Gunung Village, Semarang
Widiastuti, C., T
; Sumastuti, Efriyani
; Indriasari, Ika
; Sari, Nur Latifah Dwi Mutiara
; Saputra, Risqi Dian
; Putri, Eva Yuliana
; Suroyya, Nafis
Cooperatives, as a pillar of the people’s economy, play a strategic role in improving community welfare. However, in practice, cooperatives still face various challenges, particularly in terms of digitalisation and the limited capacity of human resources (HR). This community service activity aims to enhance digital literacy and HR capacity through assistance in implementing a digital-based financial system at Koperasi Merah Putih in Karanganyar Gunung, Semarang City. The method employed is a par...
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Optimization of Mangrove Glucomannan Addition to Improve Physicochemical Properties of Kefir
Jeki Mediantari Wahyu Wibawanti
; Zulfanita
; Dita Yuzianah
; Harisun Binti Ya’acob
; Anang Mohamad Legowo
; Setya Budi Muhammad Abduh
; Sri Mulyani
Kefir is widely recognized as a functional fermented dairy product. However, its physicochemical stability, particularly pH, acidity, and syneresis, remains a challenge during processing and storage. The addition of functional polysaccharides, such as mangrove-derived glucomannan, has been proposed to improve kefir quality. This study aimed to investigate the effect of mangrove-derived glucomannan on the physicochemical properties of kefir. A Completely Randomized Design with different concentra...
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